منابع مشابه
Variants in the SIRT1 Gene May Affect Diabetes Risk in Interaction With Prenatal Exposure to Famine
OBJECTIVE To investigate whether SIRT1, a nutrient-sensing histone deacetylase, influences fetal programming during malnutrition. RESEARCH DESIGN AND METHODS In 793 individuals of the Dutch Famine Birth Cohort, we analyzed the interaction between three SIRT1 single nucleotide polymorphisms (SNPs) and prenatal exposure to famine on type 2 diabetes risk. RESULTS In the total population (expos...
متن کاملGenetic variants of the folate metabolic system and mild hyperhomocysteinemia may affect ADHD associated behavioral problems.
An etiologically complex disorder, Attention Deficit Hyperactivity Disorder (ADHD), is often associated with various levels of cognitive deficit. Folate/vitamin B9 is crucial for numerous biochemical pathways including neural stem cell proliferation and differentiation, regulation of gene expression, neurotransmitter synthesis, myelin synthesis and repair, etc. and a scarcity has often been lin...
متن کاملMultiple associated variants increase the heritability explained for plasma lipids and coronary artery disease.
BACKGROUND Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40% to 60%. However, top variants detected by large-scale genome-wide association studies explain only a fraction of the total variance in plasma lipid phenotypes and CAD. METHODS AND RESULTS We performed a conditional and joint association analysis using ...
متن کاملASICs may affect GABAergic synapses
Currents activated in the neuronal membrane by extracellular acidification were first reported in 1980 [1]. The existence of specific proton-activated receptor was postulated. In 1997 this receptor was cloned and named “acid-sensing ion channel”, ASIC [2]. There are at least six different ASIC subunits (ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3, and ASIC4) coded by four different genes. All ASICs b...
متن کاملMeasuring missing heritability: inferring the contribution of common variants.
Genome-wide association studies (GWASs), also called common variant association studies (CVASs), have uncovered thousands of genetic variants associated with hundreds of diseases. However, the variants that reach statistical significance typically explain only a small fraction of the heritability. One explanation for the "missing heritability" is that there are many additional disease-associate...
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ژورنال
عنوان ژورنال: Science
سال: 2018
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.360.6394.1199-e